Mechanobiology: Forging a strong matrix at tendons

Clara Sidor; Frank Schnorrer

doi:10.1016/j.cub.2021.01.092

Mechanobiology: Forging a strong matrix at tendons

Curr Biol. 2021 Apr 12;31(7):R347-R350. doi: 10.1016/j.cub.2021.01.092.

Authors

Clara Sidor¹, Frank Schnorrer²

Affiliations

¹ Turing Center for Living Systems, Aix Marseille University, CNRS, IBDM, 13288 Marseille, France.
² Turing Center for Living Systems, Aix Marseille University, CNRS, IBDM, 13288 Marseille, France. Electronic address: frank.schnorrer@univ-amu.fr.

PMID: 33848491
DOI: 10.1016/j.cub.2021.01.092

Abstract

Nature faces the challenge of stably attaching soft muscles to a stiff skeleton. A new study combines live imaging and fly genetics to reveal that mechanical tension and a putative intracellular chaperone assist in assembling the gigantic extracellular matrix protein Dumpy at fly tendon-skeleton interfaces.

Publication types

Comment

MeSH terms

Biophysics
Extracellular Matrix Proteins*
Stress, Mechanical
Tendons*

Substances

Extracellular Matrix Proteins