Unified Total Syntheses of (±)-Sessilifoliamides B, C, and D

Org Lett. 2021 May 7;23(9):3437-3441. doi: 10.1021/acs.orglett.1c00895. Epub 2021 Apr 13.

Abstract

The first total syntheses of the Stemona alkaloids sessilifoliamides B and D and the second synthesis of sessilifoliamide C have been completed from a simple pyrrole substrate. The bicyclic lactam core was prepared on a gram scale via a Brønsted acid mediated cyclization and controlled oxidation with Dess-Martin periodinane. This delivered sessilifoliamide C (and its C-11 epimer) in 24% yield over 11 steps, and sessilifoliamides B and D in 13 and 17 steps, respectively.

Publication types

  • Research Support, Non-U.S. Gov't