Alcohol is the dominant cause of liver disease in Denmark. Around 1,000 persons, usually of 40 to 70 years of age, are diagnosed with alcohol-related liver disease (ALD) each year in Denmark. ALD is usually preceded by several years of heavy drinking, during which alcohol cessation could have prevented manifest ALD as argued in this review. There is a substantial inequality in ALD incidence by geography and socioeconomic status in Denmark. ALD is associated with a high mortality: The five-year mortality risk is 54%, although the prognosis for patients with ALD has improved in recent years.