The good and bad of adipose tissue macrophage exosomes in obesity

Cell Metab. 2021 Apr 6;33(4):700-702. doi: 10.1016/j.cmet.2021.03.011.

Abstract

Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk, which decreased inflammation and improved insulin signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adipose Tissue
  • Animals
  • Exosomes*
  • Inflammation
  • Insulin Resistance*
  • Macrophages
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs* / genetics
  • Obesity

Substances

  • MicroRNAs