Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice

Hypertension. 2021 Jun;77(6):1940-1952. doi: 10.1161/HYPERTENSIONAHA.120.16458. Epub 2021 Apr 5.

Ying Wang^#^{1

2}, Jian Wang^#^{2

3}, Rong Yang^#¹, Piwen Wang², Rene Porche², Samuel Kim², Kabirullah Lutfy^{2

4}, Limei Liu⁵, Theodore C Friedman^{2

6}, Meisheng Jiang⁷, Yanjun Liu^{1

2

6}

¹ Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (Y.W., R.Y., Y.L.).
² Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
³ Department of Neonatology, The First Hospital of Jilin University, Changchun, China (J.W.).
⁴ College of Pharmacy, Western University of Health Sciences, Pomona, CA (K.L.).
⁵ Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, China (L.L.).
⁶ David Geffen School of Medicine at University of California, Los Angeles (T.C.F., Y.L.).
⁷ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (M.J.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: AKT; CEBP-beta; ENaC; blood pressure; mineralocorticoid receptor; nicotine; spironolactone.