Comparison of Inflammation-based Prognostic Scores in Patients With Biliary Tract Cancer After Surgical Resection

Anticancer Res. 2021 Apr;41(4):2147-2155. doi: 10.21873/anticanres.14987.

Abstract

Background/aim: Inflammation-based prognostic scores are proven prognostic biomarkers in various cancers. This study aimed to identify a useful prognostic score for patients with biliary tract cancer (BTC) after surgical resection.

Patients and methods: This retrospective study recruited 115 patients with BTC during 2010-2020. The relationship between clinicopathological variables, including various prognostic scores and overall survival (OS), was investigated using univariate and multivariate analyses.

Results: BTC included 58 cholangiocarcinoma, 29 gallbladder carcinoma, 16 ampullary carcinoma, and 12 perihilar cholangiocarcinoma cases. A significant difference was detected in OS of patients with a Japanese modified Glasgow prognostic score (JmGPS) 0 (n=62) and JmGPS 1 or 2 (high JmGPS) (n=53). In the multivariate analysis, tumour differentiation (p=0.014) and a high JmGPS (p=0.047) were independent prognostic factors.

Conclusion: The high JmGPS was an independent prognostic predictor after surgical resection and was superior to other prognostic scores.

Keywords: Biliary tract cancer; inflammation-based prognostic score; modified Glasgow prognostic score; prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Ampulla of Vater / metabolism
  • Ampulla of Vater / pathology
  • Ampulla of Vater / surgery
  • Bile Duct Neoplasms / diagnosis
  • Bile Duct Neoplasms / metabolism
  • Bile Duct Neoplasms / mortality
  • Bile Duct Neoplasms / surgery
  • Bile Ducts, Intrahepatic / metabolism
  • Bile Ducts, Intrahepatic / pathology
  • Bile Ducts, Intrahepatic / surgery
  • Biliary Tract Neoplasms / diagnosis*
  • Biliary Tract Neoplasms / metabolism
  • Biliary Tract Neoplasms / mortality
  • Biliary Tract Neoplasms / surgery*
  • Biomarkers, Tumor / metabolism
  • C-Reactive Protein / metabolism
  • Cholangiocarcinoma / diagnosis*
  • Cholangiocarcinoma / metabolism
  • Cholangiocarcinoma / mortality
  • Cholangiocarcinoma / surgery*
  • Common Bile Duct Neoplasms / diagnosis
  • Common Bile Duct Neoplasms / metabolism
  • Common Bile Duct Neoplasms / mortality
  • Common Bile Duct Neoplasms / surgery
  • Female
  • Gallbladder Neoplasms / diagnosis
  • Gallbladder Neoplasms / metabolism
  • Gallbladder Neoplasms / mortality
  • Gallbladder Neoplasms / surgery
  • Humans
  • Inflammation / diagnosis*
  • Inflammation / metabolism
  • Japan / epidemiology
  • Klatskin Tumor / diagnosis
  • Klatskin Tumor / metabolism
  • Klatskin Tumor / mortality
  • Klatskin Tumor / surgery
  • Male
  • Middle Aged
  • Postoperative Period
  • Predictive Value of Tests
  • Prognosis
  • Research Design
  • Retrospective Studies
  • Sensitivity and Specificity
  • Survival Analysis
  • Treatment Outcome

Substances

  • Biomarkers, Tumor
  • C-Reactive Protein