Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019

Antimicrob Agents Chemother. 2021 May 18;65(6):e02718-20. doi: 10.1128/AAC.02718-20. Print 2021 May 18.

Abstract

Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.

Keywords: antivirals; baloxavir; favipiravir; next-generation sequencing; pimodivir; whole-genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Drug Resistance, Viral / genetics
  • Humans
  • Influenza A virus* / genetics
  • Influenza, Human* / drug therapy
  • Influenza, Human* / epidemiology
  • Spain / epidemiology

Substances

  • Antiviral Agents