The Categorization of Pain in Systemic Lupus Erythematosus

Rheum Dis Clin North Am. 2021 May;47(2):215-228. doi: 10.1016/j.rdc.2020.12.004. Epub 2021 Feb 25.

Abstract

Systemic lupus erythematous is a systemic autoimmune disease that can cause severe pain and impair quality of life. Pain in lupus can arise from a variety of mechanisms and is usually assessed in terms of activity and damage. In contrast, categorization of symptoms as type 1 and type 2 manifestations encompasses a broader array of symptoms, including widespread pain, fatigue, and depression that may track together. The categorization of symptoms as type 1 and type 2 manifestations can facilitate communication between patient and provider as well as provide a framework to address more fully the complex symptoms experienced by patients.

Keywords: Arthritis; Autoimmunity; Depression; Fibromyalgia; Immunosuppression; Pain; Quality of life; Systemic lupus erythematosus.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Fatigue / etiology
  • Humans
  • Lupus Erythematosus, Systemic* / complications
  • Pain / etiology
  • Quality of Life*