Successful treatment of T/myeloid mixed-phenotype acute leukemia with the translocation (10;11)(p13;q14) PICALM/AF10 with 3 + 7 myeloid standard treatment: A case report

Daphné Krzisch; Alexandra Zduniak; Elena-Liana Veresezan; Sylvie Daliphard; Nathalie Contentin; Dominique Penther; Pascaline Etancelin; Fabrice Jardin; Vincent Camus

doi:10.1002/ccr3.3815

Successful treatment of T/myeloid mixed-phenotype acute leukemia with the translocation (10;11)(p13;q14) PICALM/AF10 with 3 + 7 myeloid standard treatment: A case report

Clin Case Rep. 2021 Jan 29;9(3):1507-1513. doi: 10.1002/ccr3.3815. eCollection 2021 Mar.

Authors

Daphné Krzisch¹, Alexandra Zduniak¹, Elena-Liana Veresezan², Sylvie Daliphard³, Nathalie Contentin¹, Dominique Penther⁴, Pascaline Etancelin⁴, Fabrice Jardin¹, Vincent Camus¹

Affiliations

¹ Inserm U1245 and Department of Hematology Centre Henri Becquerel and Normandie Univ UNIROUEN Rouen France.
² Department of Pathology Centre Henri Becquerel Rouen France.
³ Department of Biological Hematology Charles Nicolle University Hospital Rouen France.
⁴ Department of Genetic Oncology Centre Henri Becquerel Rouen France.

Abstract

The translocation PICALM/AF10 is described in multilineage diseases. We report a patient with PICALM/AF10 T/myeloid mixed-phenotype acute leukemia who achieved durable complete remission after AML-like treatment suggesting a myeloid origin.

Keywords: PICALM‐AF10; mixed‐phenotype acute leukemia; translocation (1011)(p13q14).

Publication types

Case Reports