Hydroxylation and oxidation of nalidixic acid in the turtle Pseudemys scripta elegans

Vet Q. 1988 Jan;10(1):67-9. doi: 10.1080/01652176.1988.9694149.

Abstract

The turtle Pseudemys scripta elegans hydroxylates nalidixic acid into 7-hydroxynalidixic acid; this latter metabolite is oxidised into 7-carboxynalidixic acid. The elimination half-life of nalidixic acid in the turtle is 30 h. No glucuronides of nalidixic- and 7-hydroxynalidixic acid are formed, as they are in man.

MeSH terms

  • Animals
  • Hydroxylation
  • Nalidixic Acid / analogs & derivatives
  • Nalidixic Acid / biosynthesis
  • Nalidixic Acid / metabolism*
  • Oxidation-Reduction
  • Turtles / metabolism*

Substances

  • 7-hydroxynalidixic acid
  • Nalidixic Acid