In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain. The complete sequence of the viral genome revealed circulation of a new virus because the genotype differs from that of the virus responsible for another case in 2016. Practitioners should be alert to possible new cases.
Keywords: Crimean Congo hemorrhagic fever virus; Hyalomma; RT-PCR; Spain; molecular epidemiology; phylogenetic analyses; reassortant; tick-borne illness; ticks; vector-borne infections; viruses; zoonoses.