Biomarkers in Acute Kidney Injury

Win Kulvichit; John A Kellum; Nattachai Srisawat

doi:10.1016/j.ccc.2020.11.012

Biomarkers in Acute Kidney Injury

Crit Care Clin. 2021 Apr;37(2):385-398. doi: 10.1016/j.ccc.2020.11.012.

Authors

Win Kulvichit¹, John A Kellum², Nattachai Srisawat³

Affiliations

¹ Division of Nephrology, Faculty of Medicine, Chulalongkorn University, 10th Floor, Bhumisiri mangkhalanusorn Building, Ratchadamri Road, Pathum Wan, Bangkok 10330, Thailand; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, 1873 Rama IV Road, Pathum Wan, Bangkok 10330, Thailand.
² Department of Critical Care Medicine, Center for Critical Care Nephrology, The CRISMA Center, University of Pittsburgh School of Medicine, 3347 Forbes Avenue, Suite 220, Pittsburgh, PA 15213, USA.
³ Division of Nephrology, Faculty of Medicine, Chulalongkorn University, 10th Floor, Bhumisiri mangkhalanusorn Building, Ratchadamri Road, Pathum Wan, Bangkok 10330, Thailand; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, 1873 Rama IV Road, Pathum Wan, Bangkok 10330, Thailand; Department of Critical Care Medicine, Center for Critical Care Nephrology, The CRISMA Center, University of Pittsburgh School of Medicine, 3347 Forbes Avenue, Suite 220, Pittsburgh, PA 15213, USA; Critical Care Nephrology Research Unit, Chulalongkorn University, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand; Excellence Center for Critical Care Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Electronic address: drnattachai@yahoo.com.

PMID: 33752862
DOI: 10.1016/j.ccc.2020.11.012

Abstract

Biomarkers have become a pillar of precision medicine in acute kidney injury (AKI). Traditional markers for diagnosis of AKI are insensitive and insufficient to provide comprehensive information for prognostication. Several emerging biomarkers have shown promising results in large-scale clinical studies. These novel markers likely will be beneficial for personalized AKI prevention and treatment.

Keywords: AKI; Biomarkers; CCL14; IGFBP7; NGAL; TIMP-2.

Publication types

Review

MeSH terms

Acute Kidney Injury* / diagnosis
Biomarkers
Humans
Insulin-Like Growth Factor Binding Proteins*
Tissue Inhibitor of Metalloproteinase-2

Substances

Biomarkers
Insulin-Like Growth Factor Binding Proteins
Tissue Inhibitor of Metalloproteinase-2