4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts

Hypertension. 2021 Jun;77(6):1918-1927. doi: 10.1161/HYPERTENSIONAHA.120.15247. Epub 2021 Mar 22.

Authors

Katarzyna Hackert, Susanne Homann¹, Shakila Mir¹, Arne Beran¹, Simone Gorreßen¹, Florian Funk¹, Jens W Fischer¹, Maria Grandoch¹, Joachim P Schmitt¹

Affiliation

¹ From the Institute of Pharmacology and Clinical Pharmacology, and Cardiovascular Research Institute Düsseldorf (CARID), University Hospital Düsseldorf, Germany.

PMID: 33745300
DOI: 10.1161/HYPERTENSIONAHA.120.15247

Abstract

[Figure: see text].

Keywords: extracellular matrix; fibrosis; hypertrophy; inflammation; macrophages; pressure overload.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Flow Cytometry
Heart / drug effects*
Heart / physiopathology
Hymecromone / pharmacology*
Hypertrophy, Left Ventricular / metabolism
Hypertrophy, Left Ventricular / physiopathology*
Macrophages / drug effects*
Male
Mice
Myocardium / metabolism*
Ventricular Remodeling / drug effects*

Substances

Hymecromone