Timing isn't everything: opposing roles for perisomatic inhibition

Adam P Caccavano; Chris J McBain

doi:10.1016/j.neuron.2021.02.022

Timing isn't everything: opposing roles for perisomatic inhibition

Neuron. 2021 Mar 17;109(6):911-913. doi: 10.1016/j.neuron.2021.02.022.

Authors

Adam P Caccavano¹, Chris J McBain²

Affiliations

¹ Laboratory of Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
² Laboratory of Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: mcbainc@mail.nih.gov.

PMID: 33735612
DOI: 10.1016/j.neuron.2021.02.022

Abstract

Perisomatic inhibition from parvalbumin-containing (PV) interneurons is critical for timing, but the role of cholecystokinin-containing (CCK) interneurons remains obscure. Utilizing a novel mouse model, Dudok et al. demonstrate fundamentally distinct behavioral roles for these neuronal subpopulations during behavior.

Published by Elsevier Inc.

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MeSH terms

Animals
Cholecystokinin
Interneurons*
Mice
Parvalbumins*

Substances

Parvalbumins
Cholecystokinin