Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests

Open Forum Infect Dis. 2021 Jan 28;8(3):ofab043. doi: 10.1093/ofid/ofab043. eCollection 2021 Mar.

Abstract

A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.

Keywords: COVID-19; diagnostic microbiology; public health; rapid point-of-care test; serology.