Lessons learned: new insights on the role of cytokines in COVID-19

Maja Buszko; Aleksandra Nita-Lazar; Jung-Hyun Park; Pamela L Schwartzberg; Daniela Verthelyi; Howard A Young; Amy S Rosenberg

doi:10.1038/s41590-021-00901-9

Lessons learned: new insights on the role of cytokines in COVID-19

Nat Immunol. 2021 Apr;22(4):404-411. doi: 10.1038/s41590-021-00901-9.

Authors

Maja Buszko¹, Aleksandra Nita-Lazar², Jung-Hyun Park³, Pamela L Schwartzberg⁴, Daniela Verthelyi⁵, Howard A Young⁶, Amy S Rosenberg⁷

Affiliations

¹ Cellular Immunology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. maja.buszko@nih.gov.
² Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
³ Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
⁴ Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
⁵ Laboratory of Innate Immunity, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
⁶ Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, USA.
⁷ Laboratory of Immunology, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Abstract

In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of COVID-19 immunity, including long-term consequences, potential associations with autoimmunity and the multisystem inflammatory syndrome in children (MIS-C).

Publication types

Congress
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Age Factors
Animals
Autoimmunity
Biomedical Research*
COVID-19 / immunology*
COVID-19 / metabolism
COVID-19 / therapy
COVID-19 / virology
Cytokine Release Syndrome / immunology*
Cytokine Release Syndrome / metabolism
Cytokine Release Syndrome / virology
Cytokines / immunology*
Cytokines / metabolism
Host-Pathogen Interactions
Humans
Immune System / immunology*
Immune System / metabolism
Immune System / virology
Prognosis
Risk Factors
SARS-CoV-2 / immunology*
SARS-CoV-2 / pathogenicity
Systemic Inflammatory Response Syndrome / immunology*
Systemic Inflammatory Response Syndrome / metabolism
Systemic Inflammatory Response Syndrome / therapy
Systemic Inflammatory Response Syndrome / virology

Substances

Cytokines

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related

Grants and funding

Z99 CA999999/ImNIH/Intramural NIH HHS/United States