Abstract
The organic Ca2+ entry blockers nimodipine, verapamil, flunarizine and diltiazem belong to different chemical classes but antagonized, at the concentrations of 1 and 10 microM, the inhibitory effect exerted by 1-10 microM dopamine on in vitro prolactin secretion from the pituitary gland. The results suggest a close functional interaction between Ca2+ entry blockers and the dopamine receptors involved in the inhibition of prolactin secretion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium Channel Blockers / pharmacology*
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Diltiazem / pharmacology
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Dopamine Antagonists*
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Flunarizine / pharmacology
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In Vitro Techniques
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Nimodipine / pharmacology
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Prolactin / metabolism*
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects
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Verapamil / pharmacology
Substances
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Calcium Channel Blockers
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Dopamine Antagonists
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Receptors, Dopamine
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Nimodipine
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Prolactin
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Verapamil
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Diltiazem
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Flunarizine