CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody switch

Leukemia. 2021 Nov;35(11):3309-3313. doi: 10.1038/s41375-021-01208-2. Epub 2021 Mar 12.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • CD13 Antigens / immunology*
  • Cell Proliferation
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Leukemia, Myeloid, Acute / immunology
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / therapy*
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Single-Domain Antibodies / immunology*
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Single-Domain Antibodies
  • CD13 Antigens