Management of Rhabdomyosarcoma in Pediatric Patients

Timothy N Rogers; Roshni Dasgupta

doi:10.1016/j.soc.2020.11.003

Management of Rhabdomyosarcoma in Pediatric Patients

Surg Oncol Clin N Am. 2021 Apr;30(2):339-353. doi: 10.1016/j.soc.2020.11.003. Epub 2021 Jan 27.

Authors

Timothy N Rogers¹, Roshni Dasgupta²

Affiliations

¹ Department of Pediatric Surgery, University Hospitals Bristol NHS Foundation Trust, Bristol, UK. Electronic address: timothy.rogers@uhbristol.nhs.uk.
² Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

PMID: 33706904
DOI: 10.1016/j.soc.2020.11.003

Abstract

Rhabdomyosarcoma is the commonest soft tissue sarcoma in children. Clinicians need vigilance to recognize the different signs and symptoms this tumor can present with because of variable sites of origin. Diagnosis requires a safe biopsy that obtains sufficient tissue for pathologic, genetic, and biological characterization of the tumor. Treatment depends on accurate staging with imaging and surgical sampling of draining lymph nodes. A multidisciplinary team assigns patients to risk-based therapy. Patients require chemotherapy and usually a combination of complex, site-specific surgery and/or radiotherapy. Outcomes for localized rhabdomyosarcoma continue to improve but new treatments are required for metastatic and relapsed disease.

Keywords: Pediatric; Rhabdomyosarcoma; Soft tissue sarcoma; Surgery.

Publication types

Review

MeSH terms

Child
Humans
Rhabdomyosarcoma* / diagnosis
Rhabdomyosarcoma* / therapy
Sarcoma*
Soft Tissue Neoplasms* / therapy