MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease

Circ Res. 2021 Apr 16;128(8):1173-1190. doi: 10.1161/CIRCRESAHA.120.318124. Epub 2021 Mar 11.

¹ The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.
² Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).
³ German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).
⁴ Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine (A.v.K.), University of Edinburgh, Edinburgh, Scotland.
⁵ The Roslin Institute and Royal (Dick) School of Veterinary Studies (R.S.T.), University of Edinburgh, Edinburgh, Scotland.
⁶ The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland.
⁷ Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.).
⁸ BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.).
⁹ The Zena and Michael A. Wiener Cardiovascular Institute, School of Medicine at Mount Sinai, New York, New York (J.C.K.).
¹⁰ Victor Chang Cardiac Research Institute, Darlinghurst, Australia. (J.C.K.).
¹¹ Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel (I.U.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: endothelial cells; lncRNA; microRNAs; pulmonary arterial hypertension; vascular remodeling.