A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood

Chem Commun (Camb). 2021 Apr 11;57(28):3508-3511. doi: 10.1039/d1cc00519g. Epub 2021 Mar 10.

Abstract

A novel mitochondria-targeting molecular rotator FD was designed to visualize changes in viscosity under hypoxic conditions in vitro and in vivo. Importantly, FD can be used to detect changes in the blood viscosity of liver cancer and liver cirrhosis patients, and also rehabilitation of liver disease.

MeSH terms

  • Density Functional Theory
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Liver Cirrhosis / blood*
  • Liver Cirrhosis / diagnostic imaging
  • Liver Cirrhosis / metabolism
  • Liver Neoplasms / blood*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / metabolism
  • Mitochondria / chemistry
  • Mitochondria / metabolism*
  • Molecular Structure
  • Optical Imaging
  • Viscosity

Substances

  • Fluorescent Dyes