Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity

Giulia Guiducci; Lovorka Stojic

doi:10.1016/j.tig.2021.01.006

Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity

Trends Genet. 2021 Jun;37(6):528-546. doi: 10.1016/j.tig.2021.01.006. Epub 2021 Mar 5.

Authors

Giulia Guiducci¹, Lovorka Stojic²

Affiliations

¹ Barts Cancer Institute, Centre for Cancer Cell and Molecular Biology, John Vane Science Centre, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.
² Barts Cancer Institute, Centre for Cancer Cell and Molecular Biology, John Vane Science Centre, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: l.stojic@qmul.ac.uk.

PMID: 33685661
DOI: 10.1016/j.tig.2021.01.006

Abstract

The cell cycle is controlled by guardian proteins that coordinate the process of cell growth and cell division. Alterations in these processes lead to genome instability, which has a causal link to many human diseases. Beyond their well-characterized role of influencing protein-coding genes, an increasing body of evidence has revealed that long noncoding RNAs (lncRNAs) actively participate in regulation of the cell cycle and safeguarding of genome integrity. LncRNAs are versatile molecules that act via a wide array of mechanisms. In this review, we discuss how lncRNAs are implicated in control of the cell cycle and maintenance of genome stability and how changes in lncRNA-regulatory networks lead to proliferative diseases such as cancer.

Keywords: cancer; cell cycle; cell division; genome stability; long noncoding RNAs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle / genetics*
DNA Damage / genetics
DNA Repair / genetics
Genomic Instability / genetics*
Humans
Neoplasms / genetics
RNA, Long Noncoding / physiology*

Substances

RNA, Long Noncoding