Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI

Emilie Malézieux; Lucy Meunier; Benjamin Rivière; Dominique Larrey

doi:10.1016/j.clinre.2020.101599

Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI

Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101599. doi: 10.1016/j.clinre.2020.101599. Epub 2021 Mar 3.

Authors

Emilie Malézieux¹, Lucy Meunier², Benjamin Rivière³, Dominique Larrey¹

Affiliations

¹ Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France.
² Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France. Electronic address: lucy.meunier@chu-montpellier.fr.
³ Department of Pathology, St-Eloi University Hospital, Montpellier, France.

PMID: 33676268
DOI: 10.1016/j.clinre.2020.101599

Abstract

Thiazide diuretics are prescribed daily and rarely hepatotoxic. We report the case of 86-year-old woman who was admitted in hospital for jaundice after taking hydrochlorothiazide. All differential diagnoses have been eliminated. The liver biopsy was compatible with drug-induced hepatitis. Clinical and biological manifestations improved after discontinuation of the treatment. The reported case is compared to three other cases in the literature.

Keywords: Acute hepatitis; DILI; Hepatotoxicity; Hydrochlorothiazide; Thiazide diuretics.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Biopsy
Chemical and Drug Induced Liver Injury* / diagnosis
Chemical and Drug Induced Liver Injury* / etiology
Diagnosis, Differential
Female
Humans
Hydrochlorothiazide* / adverse effects

Substances

Hydrochlorothiazide