[Recurrent meningitis revealing a Bing-Neel syndrome]

Rev Med Interne. 2021 May;42(5):359-362. doi: 10.1016/j.revmed.2021.02.012. Epub 2021 Mar 2.
[Article in French]

Abstract

Introduction: Bing-Neel syndrome is a rare complication of Waldenström macroglobulinemia, defined by monoclonal lymphoplasmocytic cells in the cerebrospinal fluid or in central nervous system biopsy.

Case report: We report a 47-year-old man, with no prior history, who presented a recurrent aseptic lymphocytic meningitis with central nervous manifestations. The presence of a monoclonal lymphoplasmacytic proliferation in cerebrospinal fluid, blood and bone marrow biopsy results was compatible with a diagnosis of Bing-Neel syndrome. Despite the absence of any specific treatment, there was no recurrence of symptoms at 4-month follow-up, and the MRI lesions remained stable.

Conclusion: We report a case of Bing-Neel syndrome revealed by a recurrent meningitis. Outcome without treatment was favorable at 4-month follow-up.

Keywords: Bing-Neel syndrome; Central nervous system; Lymphome lymphoplasmocytaire; Lymphoplamacytic lymphoma; Macroglobulinémie de Waldenström; Méningite récidivante; Recurrent meningitis; Syndrome de Bing-Neel; Système nerveux central; Waldenström macroglobulinaemia.

Publication types

  • Case Reports

MeSH terms

  • Brain Diseases*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Meningitis* / diagnosis
  • Meningitis* / etiology
  • Middle Aged
  • Syndrome
  • Waldenstrom Macroglobulinemia* / complications
  • Waldenstrom Macroglobulinemia* / diagnosis