Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Maud Gratuze; David M Holtzman

doi:10.1016/j.neuron.2021.02.014

Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Neuron. 2021 Mar 3;109(5):741-743. doi: 10.1016/j.neuron.2021.02.014.

Authors

Maud Gratuze¹, David M Holtzman²

Affiliations

¹ Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: holtzman@wustl.edu.

PMID: 33662267
DOI: 10.1016/j.neuron.2021.02.014

Abstract

Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

Publication types

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MeSH terms

Alzheimer Disease*
Animals
Disease Models, Animal
Hippocampus / metabolism
Memory Disorders
Microglia / metabolism
Synaptogyrins
Tauopathies*
tau Proteins / metabolism

Substances

Synaptogyrins
tau Proteins