Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

Sunil Kumar; Muhammad Umer Ashraf; Anil Kumar; Yong-Soo Bae

doi:10.2174/1568026621666210303150235

Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

Curr Top Med Chem. 2021;21(8):753-766. doi: 10.2174/1568026621666210303150235.

Authors

Sunil Kumar¹, Muhammad Umer Ashraf¹, Anil Kumar², Yong-Soo Bae¹

Affiliations

¹ Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea.
² Amity Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurugram-122413, India.

PMID: 33655864
DOI: 10.2174/1568026621666210303150235

Abstract

MicroRNAs (miRNAs) are short ~18-22 nucleotide, single-stranded, non-coding RNA molecules playing a crucial role in regulating diverse biological processes and are frequently dysregulated during disease pathogenesis. Thus, targeting miRNA could be a potential candidate for therapeutic invention. This systemic review aims to summarize our current understanding regarding the role of miRNAs associated with Th2-mediated immune disorders and strategies for therapeutic drug development and current clinical trials.

Keywords: Asthma; Atopic dermatitis; Dendritic cells; Rhinitis; Th2-disorder; microRNA therapeutics.

Publication types

Systematic Review

MeSH terms

Humans
Immune System Diseases / drug therapy*
Immune System Diseases / genetics
Immune System Diseases / immunology
MicroRNAs / genetics*
Th2 Cells / immunology*

Substances

MicroRNAs