Orai1 channels were reported as critical contributors to the Ca2+ signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.
Keywords: Neuronal calcium homeostasis; Orai channels; Spine calcium signaling; Synaptic plasticity.
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