Neuroprotective gain of Apelin/APJ system

Jia-Xiu Zhou; Nian-Nian Shuai; Bo Wang; Xin Jin; Xin Kuang; Shao-Wen Tian

doi:10.1016/j.npep.2021.102131

Neuroprotective gain of Apelin/APJ system

Neuropeptides. 2021 Jun:87:102131. doi: 10.1016/j.npep.2021.102131. Epub 2021 Feb 20.

Authors

Jia-Xiu Zhou¹, Nian-Nian Shuai², Bo Wang², Xin Jin³, Xin Kuang⁴, Shao-Wen Tian⁵

Affiliations

¹ Department of Anesthesiology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 518109, PR China; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Faculty of Basic Medical Sciences, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, Guangxi 541199, PR China.
² Department of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, PR China.
³ Department of Anesthesiology, Nanhua Affiliated Hospital, University of South China, Hengyang, Hunan 421001, PR China.
⁴ Department of Anesthesiology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 518109, PR China. Electronic address: kx6924@126.com.
⁵ Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Faculty of Basic Medical Sciences, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, Guangxi 541199, PR China. Electronic address: 47089887@qq.com.

PMID: 33640616
DOI: 10.1016/j.npep.2021.102131

Abstract

Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many studies have shown that the apelin/APJ system has neuroprotective properties, such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, and regulating autophagy, blocking excitatory toxicity. Apelin/APJ system has been proven to play a role in various neurological diseases and may be a promising therapeutic target for nervous system diseases. In this paper, the neuroprotective properties of the apelin/APJ system and its role in neurologic disorders are reviewed. Further understanding of the pathophysiological effect and mechanism of the apelin/APJ system in the nervous system will help develop new therapeutic interventions for various neurological diseases.

Keywords: Apelin; Mechanism; Neurological diseases; Neuroprotective properties.

Publication types

Review

MeSH terms

Animals
Apelin / physiology*
Apelin / therapeutic use
Apelin Receptors / physiology*
Apoptosis / drug effects
Autophagy / drug effects
Brain Injuries, Traumatic / drug therapy
Brain Injuries, Traumatic / physiopathology
Epilepsy / drug therapy
Epilepsy / physiopathology
Humans
Inflammation
Ischemic Stroke / drug therapy
Ischemic Stroke / physiopathology
Mental Disorders / drug therapy
Mental Disorders / physiopathology
Mice
Models, Neurological
Nervous System Diseases / physiopathology*
Neurodegenerative Diseases / drug therapy
Neurodegenerative Diseases / physiopathology
Neuroprotective Agents / therapeutic use
Neurotoxins / pharmacology
Oxidative Stress / drug effects
Pain Management
Peptide Fragments / pharmacology
Peptide Fragments / therapeutic use
Rats
Signal Transduction / drug effects
Signal Transduction / physiology

Substances

Apelin
Apelin Receptors
Neuroprotective Agents
Neurotoxins
Peptide Fragments