A 12-genus bacterial signature identifies a group of severe autistic children with differential sensory behavior and brain structures

Kai Shi; Lingli Zhang; Juehua Yu; Zilin Chen; Senying Lai; Xingzhong Zhao; Wei-Guang Li; Qiang Luo; Wei Lin; Jianfeng Feng; Peer Bork; Xing-Ming Zhao; Fei Li

doi:10.1002/ctm2.314

A 12-genus bacterial signature identifies a group of severe autistic children with differential sensory behavior and brain structures

Clin Transl Med. 2021 Feb;11(2):e314. doi: 10.1002/ctm2.314.

Authors

Kai Shi^{1

2

3}, Lingli Zhang^{4

5}, Juehua Yu^{4

6}, Zilin Chen^{4

5}, Senying Lai¹, Xingzhong Zhao¹, Wei-Guang Li⁷, Qiang Luo¹, Wei Lin^{1

2

8}, Jianfeng Feng¹, Peer Bork⁹, Xing-Ming Zhao^{1

10}, Fei Li^{4

5}

Affiliations

¹ Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.
² School of Mathematical Sciences, SCMS, and SCAM, Fudan University, Shanghai, China.
³ College of Information Science and Engineering, Guilin University of Technology, Guilin, China.
⁴ Department of Developmental and Behavioural Pediatric & Child Primary Care, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁵ Brain and Behavioural Research Unit of Shanghai Institute for Pediatric Research and MOE Shanghai Key Laboratory for Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ NHC Key Laboratory of Drug Addiction Medicine (Kunming Medical University), First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
⁷ Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁸ Research Institute of Intelligent Complex Systems, Fudan University, Shanghai, China.
⁹ European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg, Germany.
¹⁰ MOE Key Laboratory of Computational Neuroscience and Brain-inspired Intelligence, and Frontiers Center for Brain Science, Shanghai, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autism Spectrum Disorder / microbiology*
Autism Spectrum Disorder / pathology
Autism Spectrum Disorder / psychology
Brain / diagnostic imaging
Brain / pathology*
Brain-Gut Axis
Case-Control Studies
Child
Child, Preschool
Female
Gastrointestinal Microbiome*
Humans
Machine Learning
Male
Neuroimaging
Patient Acuity