A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy

Yanqing Li; Chongchong Wang; Lin Zhou; Shaohua Wei

doi:10.1039/d1cc00645b

A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy

Chem Commun (Camb). 2021 Mar 28;57(25):3127-3130. doi: 10.1039/d1cc00645b. Epub 2021 Feb 25.

Authors

Yanqing Li¹, Chongchong Wang, Lin Zhou, Shaohua Wei

Affiliation

¹ College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, Jiangsu 210023, China. zhoulin@njnu.edu.cn shwei@njnu.edu.cn.

PMID: 33630986
DOI: 10.1039/d1cc00645b

Abstract

A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (¹O₂) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.

MeSH terms

Cell Line, Tumor
Down-Regulation / drug effects
Down-Regulation / radiation effects
Humans
Hypoxia-Inducible Factor 1 / metabolism
Indoles / chemistry*
Indoles / pharmacology*
Isoindoles
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacology*
Photochemotherapy*
Photosensitizing Agents / chemistry*
Photosensitizing Agents / pharmacology*
Pyridones / chemistry*
Structure-Activity Relationship
Zinc Compounds

Substances

Hypoxia-Inducible Factor 1
Indoles
Isoindoles
Organometallic Compounds
Photosensitizing Agents
Pyridones
Zinc Compounds
Zn(II)-phthalocyanine
2-hydroxypyridine