Preliminary, Real-world, Multicenter Experience With Omadacycline for Mycobacterium abscessus Infections

Taylor Morrisette; Sara Alosaimy; Julie V Philley; Carly Wadle; Catessa Howard; Andrew J Webb; Michael P Veve; Melissa L Barger; Jeannette Bouchard; Tristan W Gore; Abdalhamid M Lagnf; Iman Ansari; Carlos Mejia-Chew; Keira A Cohen; Michael J Rybak

doi:10.1093/ofid/ofab002

Preliminary, Real-world, Multicenter Experience With Omadacycline for Mycobacterium abscessus Infections

Open Forum Infect Dis. 2021 Jan 7;8(2):ofab002. doi: 10.1093/ofid/ofab002. eCollection 2021 Feb.

Authors

Taylor Morrisette¹, Sara Alosaimy¹, Julie V Philley², Carly Wadle², Catessa Howard³, Andrew J Webb^{4

5}, Michael P Veve^{6

7}, Melissa L Barger⁸, Jeannette Bouchard⁹, Tristan W Gore⁹, Abdalhamid M Lagnf¹, Iman Ansari¹, Carlos Mejia-Chew¹⁰, Keira A Cohen¹¹, Michael J Rybak^{1

12

13}

Affiliations

¹ Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
² Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, University of Texas, Tyler, Texas, USA.
³ Department of Pharmacy, West Virginia University Medicine, Morgantown, West Virginia, USA.
⁴ Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
⁵ Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.
⁶ Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Knoxville, Tennessee, USA.
⁷ Department of Pharmacy, University of Tennessee Medical Center, Knoxville, Tennessee, USA.
⁸ Department of Medicine, Ventura County Medical Center, Ventura, California, USA.
⁹ College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA.
¹⁰ Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
¹¹ Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Marlyand, USA.
¹² Department of Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, Michigan, USA.
¹³ Department of Pharmacy Services, Detroit Receiving Hospital, Detroit Medical Center, Detroit, Michigan, USA.

Abstract

Twelve patients were treated with omadacycline (OMC) as part of a multidrug regimen for Mycobacterium abscessus. The majority of infections were of pulmonary origin (7/12; 58.3%). The median (interquartile range) duration of OMC was 6.2 (4.2-11.0) months. Clinical success occurred in 9/12 (75.0%) patients. Three patients experienced a possible adverse effect while on therapy.

Keywords: Mycobacterium abscessus; omadacycline; rapidly growing nontuberculous mycobacteria.

Abstract

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