Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology

Zhan Hu; Wendao Liu; Xiumeng Hua; Xiao Chen; Yuan Chang; Yiqing Hu; Zhenyu Xu; Jiangping Song

doi:10.1161/ATVBAHA.120.315373

Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1408-1427. doi: 10.1161/ATVBAHA.120.315373. Epub 2021 Feb 25.

Authors

Zhan Hu^#¹, Wendao Liu^#^{1

2}, Xiumeng Hua^#^{1

3

2}, Xiao Chen^#^{3

2}, Yuan Chang^{3

2

4}, Yiqing Hu^{3

2}, Zhenyu Xu^{3

5}, Jiangping Song^{1

3

2}

Affiliations

¹ Department of Cardiovascular Surgery (Z.H., X.H., J.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² The Cardiomyopathy Research Group at Fuwai Hospital (W.L., X.H., X.C., Y.C., Y.H., J.S.).
³ State Key Laboratory of Cardiovascular Disease (W.L., X.H., X.C., Y.C., Y.H., Z.X., J.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴ Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (Y.C.).
⁵ Department of Pathology Center, State Key Laboratory of Cardiovascular Disease (Z.X.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

^# Contributed equally.

PMID: 33626908
DOI: 10.1161/ATVBAHA.120.315373

Abstract

[Figure: see text].

Keywords: atherosclerosis; endothelial cell; physiology; sequence analysis, RNA; transcriptome; vascular disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aorta / cytology
Aorta / metabolism*
Atherosclerosis / genetics
Atherosclerosis / metabolism
Atherosclerosis / pathology
Coronary Vessels / cytology
Coronary Vessels / metabolism*
Endothelial Cells / metabolism
Female
Fibroblasts / metabolism
Gene Expression Profiling*
Gene Expression Regulation
Gene Regulatory Networks
Humans
Lymphocytes / metabolism
Macrophages / metabolism
Male
Middle Aged
Muscle, Smooth, Vascular / metabolism
Myocytes, Smooth Muscle / metabolism
Phenotype
Pulmonary Artery / cytology
Pulmonary Artery / metabolism*
RNA-Seq
Single-Cell Analysis*
Transcriptome*