Two-year toxicity of simultaneous integrated boost in hypofractionated prone breast cancer irradiation: Comparison with sequential boost in a randomized trial

Hans Van Hulle; Eline Desaunois; Vincent Vakaet; Leen Paelinck; Max Schoepen; Giselle Post; Annick Van Greveling; Bruno Speleers; Marc Mareel; Wilfried De Neve; Chris Monten; Pieter Deseyne; Liv Veldeman

doi:10.1016/j.radonc.2021.02.010

Two-year toxicity of simultaneous integrated boost in hypofractionated prone breast cancer irradiation: Comparison with sequential boost in a randomized trial

Radiother Oncol. 2021 May:158:62-66. doi: 10.1016/j.radonc.2021.02.010. Epub 2021 Feb 20.

Authors

Affiliations

¹ Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Hans.VanHulle@Ugent.be.
² Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Eline.Desaunois@Ugent.be.
³ Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Vincent.Vakaet@Ugent.be.
⁴ Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Leen.Paelinck@Uzgent.be.
⁵ Department of Human Structure and Repair, Ghent University, Belgium; Department of Industrial Systems Engineering and Product Design, Kortrijk, Belgium. Electronic address: Max.Schoepen@Ugent.be.
⁶ Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Giselle.Post@Ugent.be.
⁷ Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Annick.VanGreveling@Uzgent.be.
⁸ Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Bruno.Speleers@Ugent.be.
⁹ Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Marc.Mareel@Ugent.be.
¹⁰ Department of Human Structure and Repair, Ghent University, Belgium. Electronic address: Wilfried.DeNeve@Ugent.be.
¹¹ Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Chris.Monten@Uzgent.be.
¹² Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Pieter.Deseyne@Uzgent.be.
¹³ Department of Human Structure and Repair, Ghent University, Belgium; Department of Radiation Oncology, Ghent University Hospital, Belgium. Electronic address: Liv.Veldeman@Uzgent.be.

PMID: 33617910
DOI: 10.1016/j.radonc.2021.02.010

Abstract

Introduction: A simultaneous integrated boost (SIB) leads to less acute toxicity. Less is known for late toxicity due to SIB. In this first and only randomized trial, two-years toxicity is analysed.

Materials and methods: Physician-assessed toxicity, using the LENT SOMA scale, and photographs, analysed with the BCCT.core software, was examined for 150 patients, randomized between SIB and sequential boost (SEB).

Results: Differences in physician-assessed two-years toxicity and photographic analysis between SIB and SEB are very small and not significant.

Conclusion: There is no indication that a SIB leads to an excess in toxicity or worse cosmetic outcome at 2 years.

Keywords: Breast cancer boost; Sequental boost; Simultaneous ingetrated boost.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms* / radiotherapy
Humans
Radiation Dose Hypofractionation
Radiotherapy, Adjuvant
Radiotherapy, Intensity-Modulated*