Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte

Rafael Shimkunas; Bence Hegyi; Zhong Jian; John A Shaw; Mohammad A Kazemi-Lari; Debika Mitra; J Kent Leach; Xiaocen Li; Mark Jaradeh; Nicholas Balardi; Yi-Je Chen; Ariel L Escobar; Anthony J Baker; Julie Bossuyt; Tamas Banyasz; Nipavan Chiamvimonvat; Kit S Lam; Donald M Bers; Leighton T Izu; Ye Chen-Izu

doi:10.1161/CIRCRESAHA.120.318570

Mechanical Load Regulates Excitation-Ca²⁺ Signaling-Contraction in Cardiomyocyte

Circ Res. 2021 Mar 19;128(6):772-774. doi: 10.1161/CIRCRESAHA.120.318570. Epub 2021 Feb 19.

Authors

Rafael Shimkunas^{1

2}, Bence Hegyi¹, Zhong Jian¹, John A Shaw³, Mohammad A Kazemi-Lari³, Debika Mitra², J Kent Leach², Xiaocen Li⁴, Mark Jaradeh¹, Nicholas Balardi¹, Yi-Je Chen¹, Ariel L Escobar⁵, Anthony J Baker⁶, Julie Bossuyt¹, Tamas Banyasz^{1

7}, Nipavan Chiamvimonvat⁸, Kit S Lam⁴, Donald M Bers¹, Leighton T Izu¹, Ye Chen-Izu^{1

2

8}

Affiliations

¹ Department of Pharmacology (R.S., B.H., Z.J., M.J., N.B., Y.-J.C., J.B., T.B., D.M.B., L.T.I., Y.C.-I.), University of California, Davis.
² Department of Biomedical Engineering (R.S., D.M., J.K.L., Y.C.-I.), University of California, Davis.
³ Department of Aerospace Engineering, University of Michigan, Ann Arbor (J.A.W., M.A.K.-L.).
⁴ Department of Biochemistry and Molecular Medicine (X.L., K.S.L.), University of California, Davis.
⁵ Department of Bioengineering, University of California, Merced (A.L.E.).
⁶ Department of Medicine, University of California, San Francisco (A.J.B.).
⁷ Department of Physiology, University of Debrecen, Hungary (T.B.).
⁸ Department of Internal Medicine (N.C., Y.C.-I.), University of California, Davis.

No abstract available

Keywords: action potentials; calcium signaling; hydrogels; mechanotransduction, cellular; muscle contraction; myocytes, cardiac; polythene glycol; sarcomere; stress, mechanical.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Action Potentials
Animals
Calcium Signaling*
Cells, Cultured
Excitation Contraction Coupling*
Heart Ventricles / cytology
Hydrogels / chemistry
Myocytes, Cardiac / metabolism*
Myocytes, Cardiac / physiology
Patch-Clamp Techniques / methods
Rabbits
Stress, Mechanical*

Substances

Hydrogels

Publication types

MeSH terms

Substances

Grants and funding