KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway

Circ Res. 2021 Apr 30;128(9):1300-1316. doi: 10.1161/CIRCRESAHA.120.318503. Epub 2021 Feb 19.

Abstract

[Figure: see text].

Keywords: heart valves; mass spectrometry; signal transduction; transcription factors; valve disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aortic Valve / pathology*
  • Aortic Valve Stenosis / drug therapy
  • Aortic Valve Stenosis / prevention & control*
  • Axin Protein / metabolism
  • CCAAT-Binding Factor
  • Calcinosis / drug therapy
  • Calcinosis / prevention & control*
  • Drug Repositioning
  • Exportin 1 Protein
  • Hydrazines / therapeutic use*
  • Karyopherins / antagonists & inhibitors
  • Klotho Proteins
  • Mice
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Triazoles / therapeutic use*
  • Wnt Signaling Pathway

Substances

  • Axin Protein
  • Axin1 protein, mouse
  • CCAAT-Binding Factor
  • Hydrazines
  • Karyopherins
  • Klb protein, mouse
  • Receptors, Cytoplasmic and Nuclear
  • Triazoles
  • selinexor
  • Klotho Proteins

Supplementary concepts

  • Aortic Valve, Calcification of