Immunotherapy in lung cancer

J Surg Oncol. 2021 Mar;123(3):718-729. doi: 10.1002/jso.26347.

Abstract

Immunotherapy has emerged as an important treatment modality throughout oncology with a particularly important role in the treatment of lung cancer. Early signals showed responses could be achieved in nonsmall cell lung cancer and small cell lung cancer and these monoclonal antibodies have become standards of care for advanced stage disease. They have also shown promise in earlier-stage disease as complements to radiation or surgery, offering the potential for durable, meaningful survival gains.

Keywords: PD-1; PD-L1; checkpoint inhibitors; chemo-immunotherapy; neoadjuvant.

Publication types

  • Review

MeSH terms

  • B7-H1 Antigen / antagonists & inhibitors
  • B7-H1 Antigen / immunology
  • Clinical Trials, Phase III as Topic
  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use
  • Immunotherapy / methods*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / immunology
  • Lung Neoplasms / therapy*
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Programmed Cell Death 1 Receptor / immunology
  • Randomized Controlled Trials as Topic

Substances

  • B7-H1 Antigen
  • CD274 protein, human
  • Immune Checkpoint Inhibitors
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor