Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge

Elizabeth M Burnette; Erica N Grodin; Naomi I Eisenberger; Lara A Ray

doi:10.1093/alcalc/agaa148

Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge

Alcohol Alcohol. 2021 Oct 29;56(6):715-717. doi: 10.1093/alcalc/agaa148.

Authors

Elizabeth M Burnette^{1

2}, Erica N Grodin¹, Naomi I Eisenberger¹, Lara A Ray^{1

3

4}

Affiliations

¹ Department of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
² Neuroscience Interdepartmental Program, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
³ Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
⁴ Brain Research Institute, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.

Abstract

Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.

MeSH terms

Alcoholism / pathology*
Biomedical Research
Endotoxins / administration & dosage
Humans
Inflammation / pathology*
Lipopolysaccharides / administration & dosage*
Translational Research, Biomedical

Substances

Endotoxins
Lipopolysaccharides

Abstract

MeSH terms

Substances

Grants and funding