Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

Peter L Wang; Rafael S Czepielewski; Gwendalyn J Randolph

doi:10.1016/j.it.2021.01.008

Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

Trends Immunol. 2021 Mar;42(3):180-182. doi: 10.1016/j.it.2021.01.008. Epub 2021 Feb 6.

Authors

Peter L Wang¹, Rafael S Czepielewski¹, Gwendalyn J Randolph²

Affiliations

¹ Department of Pathology & Immunology, St. Louis, MO 63110, USA.
² Department of Pathology & Immunology, St. Louis, MO 63110, USA. Electronic address: gjrandolph@wustl.edu.

PMID: 33563563
DOI: 10.1016/j.it.2021.01.008

Abstract

The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Homeostasis
Immunity*
Lymph Nodes*
Sensory Receptor Cells
Stromal Cells