NSCs: Sentinel Cells of the Brain

Stefano Pluchino; Alexandra M Nicaise

doi:10.1016/j.stem.2020.11.016

NSCs: Sentinel Cells of the Brain

Cell Stem Cell. 2021 Feb 4;28(2):177-179. doi: 10.1016/j.stem.2020.11.016.

Authors

Stefano Pluchino¹, Alexandra M Nicaise²

Affiliations

¹ Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK. Electronic address: spp24@cam.ac.uk.
² Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

PMID: 33545074
DOI: 10.1016/j.stem.2020.11.016

Abstract

Adult neural stem cells (NSCs) have the ability to oscillate between activated and dormant states in response to extrinsic regulators. In this issue of Cell Stem Cell, Belenguer et al. (2020) identify a direct role for systemic TNF-α, which acts through its receptors TNFRII and TNFRI as a regulator of NSC activation and a return to quiescence, respectively.

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MeSH terms

Adult
Adult Stem Cells*
Brain
Humans
Inflammation
Neural Stem Cells*
Tumor Necrosis Factor-alpha

Substances

Tumor Necrosis Factor-alpha