Abstract
The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkylating Agents / chemical synthesis
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Alkylating Agents / pharmacology
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Alkylating Agents / therapeutic use*
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Animals
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Graft Rejection
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Haptens*
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Immunity, Cellular / drug effects
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Leukemia, Experimental / drug therapy
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Leukemia, Lymphoid / drug therapy
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Mice
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Mustard Compounds / chemical synthesis
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Mustard Compounds / pharmacology
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Mustard Compounds / therapeutic use*
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Neoplasms / drug therapy*
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Skin Transplantation
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Solubility
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Transplantation, Homologous
Substances
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Alkylating Agents
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Haptens
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Mustard Compounds