mSphere of Influence: Apoptotic Mimicry and Virus Entry

Melinda A Brindley

doi:10.1128/mSphere.00034-21

mSphere of Influence: Apoptotic Mimicry and Virus Entry

mSphere. 2021 Jan 27;6(1):e00034-21. doi: 10.1128/mSphere.00034-21.

Author

Melinda A Brindley¹

Affiliation

¹ Department of Infectious Diseases, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA mbrindle@uga.edu.

Abstract

Melinda A. Brindley works in the field of virology with specific interests in understanding how viruses enter cells. In this mSphere of Influence article, she reflects on how the paper "Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells" by J. Mercer and A. Helenius (Science 320:531-535, 2008, https://doi.org/10.1126/science.1155164) made an impact on her by expanding our understanding of virus-host interactions and virus-cell binding.

Keywords: apoptotic mimicry; phosphatidylserine; viral entry.

MeSH terms

Apoptosis / physiology*
Host Microbial Interactions*
Phosphatidylserines / physiology
Vaccinia virus / physiology*
Virus Internalization*

Substances

Phosphatidylserines

Grants and funding

R01 AI139238/AI/NIAID NIH HHS/United States