Significant differences in single-platelet biophysics exist across species but attenuate during clot formation

Oluwamayokun Oshinowo; Renee Copeland; Yumiko Sakurai; Meredith E Fay; Brian G Petrich; Traci Leong; Benjamin Brainard; Wilbur A Lam

doi:10.1182/bloodadvances.2020003755

Significant differences in single-platelet biophysics exist across species but attenuate during clot formation

Blood Adv. 2021 Jan 26;5(2):432-437. doi: 10.1182/bloodadvances.2020003755.

Authors

Oluwamayokun Oshinowo^{1

2

3

4}, Renee Copeland^{1

2

3

4}, Yumiko Sakurai^{1

2

3

4}, Meredith E Fay^{1

2

3

4}, Brian G Petrich², Traci Leong⁵, Benjamin Brainard⁶, Wilbur A Lam^{1

2

3

4}

Affiliations

¹ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
² Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.
³ Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.
⁴ Winship Cancer Institute and.
⁵ Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA; and.
⁶ Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA.

Abstract

Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar.
Multiple biophysical parameters integrate during clot formation, measured by bulk clot contraction, and attenuate biophysical differences.

Significant differences in single-platelet biophysics exist across species but attenuate during clot formation

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