Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle

Sci Rep. 2021 Jan 25;11(1):2140. doi: 10.1038/s41598-020-77775-8.

Abstract

The Hippo signaling pathway is a key regulator of tissue development and regeneration. Activation of the Hippo pathway leads to nuclear translocation of the YAP1 transcriptional coactivator, resulting in changes in gene expression and cell cycle entry. Recent studies have demonstrated the nuclear translocation of YAP1 during the development of the sensory organs of the inner ear, but the possible role of YAP1 in sensory regeneration of the inner ear is unclear. The present study characterized the cellular localization of YAP1 in the utricles of mice and chicks, both under normal conditions and after HC injury. During neonatal development, YAP1 expression was observed in the cytoplasm of supporting cells, and was transiently expressed in the cytoplasm of some differentiating hair cells. We also observed temporary nuclear translocation of YAP1 in supporting cells of the mouse utricle after short periods in organotypic culture. However, little or no nuclear translocation of YAP1 was observed in the utricles of neonatal or mature mice after ototoxic injury. In contrast, substantial YAP1 nuclear translocation was observed in the chicken utricle after streptomycin treatment in vitro and in vivo. Together, these data suggest that differences in YAP1 signaling may partially account for the differing regenerative abilities of the avian vs. mammalian inner ear.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Nucleus / drug effects
  • Cell Nucleus / metabolism
  • Chickens
  • Diphtheria Toxin / pharmacology
  • Female
  • Gene Expression Regulation, Developmental / drug effects
  • Hair Cells, Auditory / drug effects
  • Hair Cells, Auditory / metabolism
  • Homeodomain Proteins / metabolism
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Protein Transport / drug effects
  • Saccule and Utricle / embryology*
  • Saccule and Utricle / injuries*
  • Saccule and Utricle / metabolism
  • Saccule and Utricle / pathology
  • Transcription Factor Brn-3C / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Diphtheria Toxin
  • Homeodomain Proteins
  • Pou4f3 protein, mouse
  • Transcription Factor Brn-3C