Prevention of the TPA-mediated down-regulation of protein kinase C

Biochem Biophys Res Commun. 1988 Feb 29;151(1):94-9. doi: 10.1016/0006-291x(88)90563-3.

Abstract

Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Lymphocytes / drug effects
  • Lymphocytes / enzymology*
  • Palmitoylcarnitine / pharmacology
  • Phloretin / pharmacology
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / metabolism*
  • Sphingosine / pharmacology*
  • Tetradecanoylphorbol Acetate / pharmacology*

Substances

  • Palmitoylcarnitine
  • Protein Kinase C
  • Sphingosine
  • Tetradecanoylphorbol Acetate
  • Phloretin