NMR investigation of the copper(II)-carnosine complex in water solution

J Inorg Biochem. 1988 Jan;32(1):7-12. doi: 10.1016/0162-0134(88)80011-4.

Abstract

The predominant species in water solution of excess carnosine and Cu2+ ions was characterized by measuring 13C and 1H spin-lattice and spin-spin relaxation rates. Four peptide molecules were calculated to be coordinated to the metal through the imidazole nitrogen. Evaluation of ion-proton distances demonstrated that metal complexation does not involve severe changes in conformation of the peptide.

MeSH terms

  • Carnosine*
  • Copper*
  • Dipeptides*
  • Magnetic Resonance Spectroscopy / methods
  • Protein Conformation
  • Solutions

Substances

  • Dipeptides
  • Solutions
  • Copper
  • Carnosine