Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities

Amanguli Tuohongerbieke; Jun Li; Gulnar Sabir; Xuelei Xin; Miao Hu; Xiaomei Duan; Liu Liu; Dan Tang; Jun Zhu; Haji Akber Aisa

doi:10.1016/j.phytochem.2020.112648

Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities

Phytochemistry. 2021 Apr:184:112648. doi: 10.1016/j.phytochem.2020.112648. Epub 2021 Jan 14.

Authors

Affiliations

¹ The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100039, PR China.
² The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.
³ Xinjiang Institute of Chinese Material Medica and Ethnomedicine, Urumqi, 830002, People's Republic of China.
⁴ The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China. Electronic address: haji@ms.xjb.ac.cn.

PMID: 33454616
DOI: 10.1016/j.phytochem.2020.112648

Abstract

Nine undescribed lignanamides, limoniumins A-I, together with ten known lignanamides and two known phenolics were isolated from ethyl acetate extract of the roots of Limonium gmelinii (Plumbaginaceae). Their structures were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. Limoniumin A is the first hybrid lignanamide of phenylpropanoid and coumarin. All tested lignanamides showed significant inhibitory activity against α-glucosidase stronger than positive control and remarkable inhibitory effect to PTP1B with IC₅₀ values less than 10 μM. In addition, some lignanamides exhibited moderate cytotoxic activity against HeLa and MCF-7 cells and anti-inflammatory activity against COX-2 in a dose-dependent way.

Keywords: Anti-diabetic; Anti-inflammatory; Cytotoxic; Lignanamides; Limonium gmelinii (Willd.) Kuntze; Plumbaginaceae.

MeSH terms

Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Diabetes Mellitus* / drug therapy
Humans
Plant Roots
Plumbaginaceae*
alpha-Glucosidases

Substances

Anti-Inflammatory Agents
alpha-Glucosidases