Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus

Merve Suzan Zeden; Órla Burke; Moya Vallely; Claire Fingleton; James P O'Gara

doi:10.1371/journal.ppat.1009093

Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus

PLoS Pathog. 2021 Jan 14;17(1):e1009093. doi: 10.1371/journal.ppat.1009093. eCollection 2021 Jan.

Authors

Merve Suzan Zeden¹, Órla Burke¹, Moya Vallely¹, Claire Fingleton¹, James P O'Gara¹

Affiliation

¹ Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Transport Systems / metabolism*
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Microbial*
Humans
Peptide Transporter 1 / metabolism*
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
Staphylococcus aureus / pathogenicity
Virulence*

Substances

Amino Acid Transport Systems
Anti-Bacterial Agents
Peptide Transporter 1

Grants and funding

Sources of funding: Health Research Board grants HRA-POR-2015-1158 and ILP-POR-2019-102 to JPOG (www.hrb.ie), Irish Research Council grants GOIPG/2016/36 to CF and JPOG; GOIPG/2018/943 to MV and JPOG; and GOIPG/2019/2011 to OB and JPOG (www.research.ie); and Science Foundation Ireland grant 19/FFP/6441 to JPOG (www.sfi.ie). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.