Structural biology in the fight against COVID-19

Montserrat Bárcena; Christopher O Barnes; Martin Beck; Pamela J Bjorkman; Bruno Canard; George F Gao; Yunyun Gao; Rolf Hilgenfeld; Gerhard Hummer; Ardan Patwardhan; Gianluca Santoni; Erica Ollmann Saphire; Christiane Schaffitzel; Sharon L Schendel; Janet L Smith; Andrea Thorn; David Veesler; Peijun Zhang; Qiang Zhou

doi:10.1038/s41594-020-00544-8

Structural biology in the fight against COVID-19

Nat Struct Mol Biol. 2021 Jan;28(1):2-7. doi: 10.1038/s41594-020-00544-8.

Authors

Montserrat Bárcena¹, Christopher O Barnes², Martin Beck³, Pamela J Bjorkman², Bruno Canard⁴, George F Gao⁵, Yunyun Gao⁶, Rolf Hilgenfeld⁷, Gerhard Hummer³, Ardan Patwardhan⁸, Gianluca Santoni⁹, Erica Ollmann Saphire¹⁰, Christiane Schaffitzel¹¹, Sharon L Schendel¹⁰, Janet L Smith¹², Andrea Thorn⁶, David Veesler¹³, Peijun Zhang^{14

15}, Qiang Zhou^{16

17}

Affiliations

¹ Leiden University Medical Center, Leiden, the Netherlands.
² California Institute of Technology, Pasadena, CA, USA.
³ Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
⁴ Centre National de la Recherche Scientifique and Aix-Marseille University, Marseille, France.
⁵ CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁶ HARBOR, University of Hamburg, Hamburg, Germany.
⁷ Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
⁸ European Molecular Biology Laboratory (EMBL-EBI) European Bioinformatics Institute, Hinxton, UK.
⁹ European Synchrotron Radiation Facility, Grenoble, France.
¹⁰ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
¹¹ School of Biochemistry and Bristol Synthetic Biology Centre (BrisSynBio), University of Bristol, Bristol, UK.
¹² Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
¹³ University of Washington, Seattle, WA, USA.
¹⁴ Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
¹⁵ Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
¹⁶ Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
¹⁷ Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.

PMID: 33437043
DOI: 10.1038/s41594-020-00544-8

No abstract available

Publication types

News

MeSH terms

Computational Biology / methods
Cryoelectron Microscopy / methods
Databases, Protein
Epitopes / chemistry
Epitopes / immunology
Host-Pathogen Interactions
Humans
Linoleic Acid / chemistry
Linoleic Acid / metabolism
Linoleic Acid / pharmacology
Molecular Biology / methods*
SARS-CoV-2 / chemistry*
SARS-CoV-2 / genetics
SARS-CoV-2 / pathogenicity
Spike Glycoprotein, Coronavirus / chemistry
Spike Glycoprotein, Coronavirus / metabolism
Viral Proteins / chemistry*
Viral Proteins / metabolism
Viral Vaccines / immunology
Viral Vaccines / pharmacology
Virus Replication / physiology

Substances

Epitopes
Spike Glycoprotein, Coronavirus
Viral Proteins
Viral Vaccines
spike protein, SARS-CoV-2
Linoleic Acid

Publication types

MeSH terms

Substances

Grants and funding