Spontaneously regressed granulomatosis with polyangiitis: A case report

Hiroki Ota; Chisa Sato; Akira Igarashi; Sumito Inoue; Sakiko Masuda; Akihiro Ishizu; Masafumi Watanabe

doi:10.1016/j.resinv.2020.12.002

Spontaneously regressed granulomatosis with polyangiitis: A case report

Respir Investig. 2021 May;59(3):372-376. doi: 10.1016/j.resinv.2020.12.002. Epub 2021 Jan 9.

Authors

Hiroki Ota¹, Chisa Sato², Akira Igarashi³, Sumito Inoue⁴, Sakiko Masuda⁵, Akihiro Ishizu⁶, Masafumi Watanabe⁷

Affiliations

¹ Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: yufomho.123@gmail.com.
² Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: kitty1980112080@yahoo.co.jp.
³ Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: akigaras@med.id.yamagata-u.ac.jp.
⁴ Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: sinoue@med.id.yamagata-u.ac.jp.
⁵ Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 060-0812, Japan. Electronic address: sakikomasuda@hs.hokudai.ac.jp.
⁶ Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 060-0812, Japan. Electronic address: aishizu@med.hokudai.ac.jp.
⁷ Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: m-watanabe@med.id.yamagata-u.ac.jp.

PMID: 33431355
DOI: 10.1016/j.resinv.2020.12.002

Abstract

A 71-year-old woman presented with chest pain, cough, and back pain. A chest roentgenogram showed multiple nodular shadows in both lungs. She was diagnosed with granulomatosis with polyangiitis (GPA). The multiple nodular shadows in both lungs regressed spontaneously in a few months. There are few reports of spontaneous regression of GPA, and the underlying mechanism is unclear. Neutrophil extracellular traps (NETs) have been recently shown to be involved in GPA. NETs may also be related to the natural regression of GPA.

Keywords: Granulomatosis with polyangiitis; Myeloperoxidase-antineutrophil cytoplasmic antibody; Neutrophil extracellular traps; Spontaneous regression.

Publication types

Case Reports

MeSH terms

Aged
Back Pain / etiology
Chest Pain / etiology
Cough / etiology
Extracellular Traps*
Female
Granulomatosis with Polyangiitis / complications
Granulomatosis with Polyangiitis / diagnostic imaging*
Granulomatosis with Polyangiitis / pathology*
Humans
Lung / diagnostic imaging*
Lung / pathology*
Radiography, Thoracic
Remission, Spontaneous