Metal-Containing Poly(ionic liquid) Membranes for Antibacterial Applications

Zhiqiang Zheng; Jiangna Guo; Hailei Mao; Qiming Xu; Jing Qin; Feng Yan

doi:10.1021/acsbiomaterials.7b00165

Metal-Containing Poly(ionic liquid) Membranes for Antibacterial Applications

ACS Biomater Sci Eng. 2017 Jun 12;3(6):922-928. doi: 10.1021/acsbiomaterials.7b00165. Epub 2017 Apr 11.

Authors

Zhiqiang Zheng¹, Jiangna Guo¹, Hailei Mao², Qiming Xu², Jing Qin¹, Feng Yan¹

Affiliations

¹ Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
² Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

PMID: 33429564
DOI: 10.1021/acsbiomaterials.7b00165

Abstract

Imidazolium-type metal-containing ionic liquid (IL) monomers and their corresponding poly(ionic liquid) (PIL) membranes coordinated with CuCl₂ (PILM-Cu), FeCl₃ (PILM-Fe), or ZnCl₂ (PILM-Zn) were synthesized. The effect of metal ions on the antimicrobial activities against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was investigated. Compared with pristine PILM-Br membrane, PILM-Cu, PILM-Fe, and PILM-Zn membranes exhibit enhanced antibacterial activities due to the attributes of both imidazolium cations and metal-containing anions. Furthermore, all of the metal-containing PIL membranes present low hemolysis toward human red blood cell and high long-term antibacterial stability, even after immersion in water for 90 days, demonstrating clinical feasibility in topical applications.

Keywords: antibacterial; ionic liquids; metal-containing; poly(ionic liquid); polymer membrane.